IMMUNOGLOBULIN-M AND IMMUNOGLOBULIN-G ANTIBODY-RESPONSES TO PLASMODIUM-FALCIPARUM GLUTAMATE-RICH PROTEIN - CORRELATION WITH CLINICAL IMMUNITY IN GAMBIAN CHILDREN

被引:38
作者
DZIEGIEL, M
ROWE, P
BENNETT, S
ALLEN, SJ
OLERUP, O
GOTTSCHAU, A
BORRE, M
RILEY, EM
机构
[1] STATENS SERUM INST,DEPT INFECT IMMUNOL,DIV BIOTECHNOL,DK-2300 COPENHAGEN,DENMARK
[2] STATENS SERUM INST,DEPT BIOSTAT,DK-2300 COPENHAGEN,DENMARK
[3] UNIV LONDON LONDON SCH HYG & TROP MED,TROP HLTH EPIDEMIOL UNIT,LONDON WC1E 7HT,ENGLAND
[4] MRC LABS,BANJUL,SENEGAMBIA
[5] KAROLINSKA INST,NOVUM,CTR BIOTECHNOL,S-14186 HUDDINGE,SWEDEN
基金
英国惠康基金;
关键词
D O I
10.1128/IAI.61.1.103-108.1993
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The aims of the present study were to describe the age-related immunoglobulin M (IgM) and IgG response to part of a 220-kDa glutamate-rich protein (GLURP) from Plasmodium falciparum and to determine possible correlations of possession of these antibodies with malaria morbidity. IgM and IgG levels were measured with a recombinant fusion protein consisting of the carboxy-terminal 783 amino acids of the GLURP. Samples for the study were obtained during a longitudinal malaria morbidity survey performed in The Gambia; cross-sectional surveys were performed at the beginning of the transmission season in May and in October. Seropositivity rates increased with age to a maximum of 77% for IgM and 95% for IgG in adults. High prevalences of seropositivity were associated with certain human leukocyte antigen class II alleles (DRw8, DR9, DR7, DR4, DQw7, and DQw2) or haplotypes. The relationship between anti-GLURP489-1271 antibodies and clinical immunity is not clear; asymptomatically infected children aged 5 to 8 years had significantly higher levels of IgG than clinically ill children of the same age, suggesting that antibodies to the carboxy-terminal part of the GLURP may contribute to immunity to P. falciparum. However, this was not significant for younger children.
引用
收藏
页码:103 / 108
页数:6
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