CHANGES IN PERIPHERAL BENZODIAZEPINE RECEPTORS IN PATIENTS WITH PANIC DISORDER AND OBSESSIVE-COMPULSIVE DISORDER

被引：33

作者：

MARAZZITI, D

ROTONDO, A

MARTINI, C

GIANNACCINI, G

LUCACCHINI, A

PANCIOLIGUADAGNUCCI, ML

DIAMOND, BI

BORISON, R

CASSANO, GB

机构：

[1] UNIV PISA,IST POLICATTEDRA DISCIPLINE BIOL,I-56100 PISA,ITALY

[2] MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA

[3] AUGUSTA VAMC,AUGUSTA,GA

来源：

NEUROPSYCHOBIOLOGY | 1994年 / 29卷 / 01期

关键词：

BENZODIAZEPINES; PERIPHERAL BENZODIAZEPINE RECEPTORS; PLATELETS; PANIC DISORDER; OBSESSIVE-COMPULSIVE DISORDER;

D O I：

10.1159/000119055

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral benzodiazepine (BDZ) receptors were investigated through the binding of the specific ligand H-3-PK-11195 to platelet membranes, in 17 patients suffering from panic disorder (PD) and in 16 patients affected by obsessive-compulsive disorder (OCD). The results, showing that the density (B-max) of peripheral BDZ receptors was significantly lower in patients with PD than in controls or OC patients, suggest that the number of platelet BDZ receptors varies with different anxiety disorders and that perhaps this marker may be beneficial in differentiating some subtypes of these disorders.

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页码：8 / 11

页数：4

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