THE ORIGIN OF CD4(-)CD8(-)TCR-ALPHA-BETA(+) THYMOCYTES - A MODEL-BASED ON T-CELL RECEPTOR AVIDITY

被引：46

作者：

BUDD, RC

MIXTER, PF

机构：

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 09期

关键词：

D O I：

10.1016/0167-5699(95)80019-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ralph Budd and Philip Mixter present a hypothesis suggesting that CD4(-)CD8(-)TCR alpha beta(+) cells arising in the normal thymus result from a high-avidity T-cell receptor (TCR) signal bordering on negative selection. In normal mice, this subset is likely to be gradually deleted but, in the absence of Fas, these cells persist in lpr mice. The model they describe makes several predictions regarding the nature of this unusual T-cell subset.

引用

页码：428 / 431

页数：4

共 27 条

[21] DOWN-REGULATION OF T-CELL RECEPTORS ON SELF-REACTIVE T-CELLS AS A NOVEL MECHANISM FOR EXTRATHYMIC TOLERANCE INDUCTION [J].