MITOCHONDRIAL PERMEABILITY TRANSITION IS INDUCED BY IN-VIVO THYROID-HORMONE TREATMENT

被引:48
作者
KALDERON, B [1 ]
HERMESH, O [1 ]
BARTANA, J [1 ]
机构
[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,FAC MED,DEPT HUMAN NUTR & METAB,IL-91120 JERUSALEM,ISRAEL
关键词
D O I
10.1210/en.136.8.3552
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyroid hormone treatment in vivo results in activation of mitochondrial Ca2+ efflux and temperature-dependent enhanced swelling of Ca2+-loaded rat liver mitochondria. Thyroid hormone-induced swelling was effectively prevented in the presence of excess EGTA or cyclosporin A. Thyroid hormone treatment similarly resulted in a dramatic decrease in mitochondrial membrane potential (80%), proton gradient (45%), and proton motive force (69%) measured in Ca2+-loaded mitochondria. All three parameters were essentially restored to euthyroid values in the presence of excess EGTA or cyclosporin A. Mitochondrial energy-linked transhydrogenase activity measured in the presence of Ca2+ was 33% increased and 38% decreased in hypothyroid and L-T-3-treated hypothyroid rats, respectively, compared to that in euthyroid rats. Hence, in vivo thyroid hormone treatment may induce mitochondrial permeability transition mediated by the cyclosporin A-sensitive permeability transition pore.
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收藏
页码:3552 / 3556
页数:5
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