REAL-TIME ANALYSIS OF BREATH USING AN ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETER

被引：66

作者：

LOVETT, AM ^{[1
]}

REID, NM ^{[1
]}

BUCKLEY, JA ^{[1
]}

FRENCH, JB ^{[1
]}

CAMERON, DM ^{[1
]}

机构：

[1] UNIV TORONTO,INST AEROSP STUDIES,DOWNSVIEW M3H 5T6,ONTARIO,CANADA

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 03期

关键词：

D O I：

10.1002/bms.1200060302

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new technique is reported resulting in the direct, instantaneous analyses of trace compounds in breath. The analyses were performed using a commercial atmospheric pressure chemical ionization mass spectrometer (TAGA TM 2000 APCI mass spectrometer). A known flow of breath sample is introduced into the ionization region of the mass spectrometer. The study includes the measurement and monitoring in real‐time, of breath ammonia during a 24 hour and a 48 hour period. The ammonia profiles indicate a personalized daily pattern associated with each subject. This method appears to be of potential value in routine detection and treatment of hyperammonemia patients. Results also show that it is possible to obtain instantaneous analyses of several naturally occurring metabolites and other substances on breath in the ppm to ppt range, suggesting a number of diagnostic research applications. Copyright © 1979 Heyden & Son Ltd

引用

页码：91 / 97

页数：7

共 24 条

[11] NEW PICOGRAM DETECTION SYSTEM BASED ON A MASS-SPECTROMETER WITH AN EXTERNAL IONIZATION SOURCE AT ATMOSPHERIC-PRESSURE [J].

HORNING, EC ;

HORNING, MG ;

CARROLL, DI ;

DZIDIC, I ;

STILLWELL, RN .

ANALYTICAL CHEMISTRY, 1973, 45 (06) :936-943

[12] DETERMINATION OF AMMONIA IN BIOLOGICAL SOLUTIONS BY 2ND-DERIVATIVE SPECTROMETRY [J].

HUNT, RD ;

CADE, R ;

WILLIAMS, DT .

ANALYTICAL CHEMISTRY, 1977, 49 (01) :83-85

[13]

HUNT RD, 1977, AM LAB JUN, P9

[14]

HUNT RD, 1976, THESIS U FLORIDA

[15]

HUNT RD, 1976, PHYSIOLOGIST, V19, P235

[16]

HUNT RD, 1977, J MISS ACAD SCI, P22

[17]

HUTCHINGSON JH, 1962, J LAB CLIN MED, V60, P170

[18] DETERMINATION OF IMPURITIES IN GASES BY ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY [J].

KAMBARA, H ;

KANOMATA, I .

ANALYTICAL CHEMISTRY, 1977, 49 (02) :270-275

[19]

KOROTOSZYNSKI B, 1977, J CHROMATOGR SCI, V15, P239

[20]

REID NM, 1977, 25TH ANN C MASS SPEC, P714

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