NERVE GROWTH-FACTOR AND NEURONAL CELL-DEATH

被引：26

作者：

PEREZPOLO, JR ^{[1
]}

FOREMAN, PJ ^{[1
]}

JACKSON, GR ^{[1
]}

SHAN, D ^{[1
]}

TAGLIALATELA, G ^{[1
]}

THORPE, LW ^{[1
]}

WERRBACHPEREZ, K ^{[1
]}

机构：

[1] UNIV TEXAS, MED BRANCH, INST MARINE BIOMED, GALVESTON, TX 77550 USA

来源：

MOLECULAR NEUROBIOLOGY | 1990年 / 4卷 / 1-2期

关键词：

NGF; NGF RECEPTOR; RECEPTOR-ASSOCIATED PROTEIN; PURIFICATION; ACETYL-L-CARNITINE; AGED; CELL DEATH; NEUROTROPHIC FACTOR; GROWTH FACTOR; RETINOIC ACID; ASTROCYTE LYMPHOCYTE; MITOGEN;

D O I：

10.1007/BF02935585

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The regulation of neuronal cell death by the neuronotrophic factor, nerve growth factor (NGF), has been described during neural development and following injury to the nervous system. Also, reduced NGF activity has been reported for the aged NGF-responsive neurons of the sympathetic nervous system and cholinergic regions of the central nervous system (CNS) in aged rodents and man. Although there is some knowledge of the molecular structure of the NGF and its receptor, less is known as to the mechanism of action of NGF. Here, a possible role for NGF in the regulation of oxidant-antioxidant balance is discussed as part of a molecular explanation for the known effects of NGF on neuronal survival during development, after injury, and in the aged CNS.

引用

页码：57 / 91

页数：35

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