TYROSINASE INHIBITORS FROM ANACARDIUM-OCCIDENTALE FRUITS

被引：154

作者：

KUBO, I

KINSTHORI, I

YOKOKAWA, Y

机构：

[1] Department of Environmental Science, Policy and Management, University of California, Berkeley

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 04期

关键词：

D O I：

10.1021/np50106a021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Anacardic acids, 2-methylcardols, and cardols isolated from various parts of the cashew [Anacardium occidentale] (Anacardiaceae) fruit have been found to exhibit tyrosinase inhibitory activity. Kinetic studies with the two principal active compounds, 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid and 5-[8(Z),11(Z),14-pentadecatrienyl]resorcinol, have indicated that both of these phenolic compounds exhibit characteristic competitive inhibition of the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase.

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页码：545 / 551

页数：7

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