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CDNA SEQUENCE OF 2 DISTINCT PITUITARY PROTEINS HOMOLOGOUS TO KEX2 AND FURIN GENE-PRODUCTS - TISSUE-SPECIFIC MESSENGER-RNAS ENCODING CANDIDATES FOR PRO-HORMONE PROCESSING PROTEINASES
被引:493
作者
:
SEIDAH, NG
论文数:
0
引用数:
0
h-index:
0
机构:
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
SEIDAH, NG
[
1
]
GASPAR, L
论文数:
0
引用数:
0
h-index:
0
机构:
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
GASPAR, L
[
1
]
MION, P
论文数:
0
引用数:
0
h-index:
0
机构:
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
MION, P
[
1
]
MARCINKIEWICZ, M
论文数:
0
引用数:
0
h-index:
0
机构:
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
MARCINKIEWICZ, M
[
1
]
MBIKAY, M
论文数:
0
引用数:
0
h-index:
0
机构:
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
MBIKAY, M
[
1
]
CHRETIEN, M
论文数:
0
引用数:
0
h-index:
0
机构:
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
CHRETIEN, M
[
1
]
机构
:
[1]
CLIN RES INST MONTREAL, MOLEC NEUROENDOCRINOL LAB, MONTREAL H2W 1R7, QUEBEC, CANADA
来源
:
DNA AND CELL BIOLOGY
|
1990年
/ 9卷
/ 06期
关键词
:
D O I
:
10.1089/dna.1990.9.415
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
Based on the concept of sequence conservation around the active sites of serine proteinases, polymerase chain reaction applied to mRNA amplification allowed us to obtain a 260-bp probe which was used to screen a mouse pituitary cDNA library. The primers used derived from the cDNA sequence of active sites Ser* and Asn* of human furin. Two cDNA sequences were obtained from a number of positive clones. These code for two similar but distinct structures (mPCl and mPC2), each being homologous to yeast Kex2 and human furin. In situ hybridization (mPCl) and Northern blots (mPCl = 3.0 kb and mPC2 = 2.8 and 4.8 kb) demonstrated tissue and cellular specificity of expression, only within endocrine and neuroendocrine cells. These data suggest that mPCl and mPC2 represent prime candidates for tissue-specific pro-hormone converting proteinases. © 1990, Mary Ann Liebert, Inc. All rights reserved.
引用
收藏
页码:415 / 424
页数:10
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(22)
:7911
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共 32 条
[31]
WATSON SJ, 1987, IN SITU HYBRIDIZATIO, P126
[32]
CLONING, SEQUENCING, AND SECRETION OF BACILLUS-AMYLOLIQUEFACIENS SUBTILISIN IN BACILLUS-SUBTILIS
[J].
WELLS, JA
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC,DEPT MOLEC BIOL,SAN FRANCISCO,CA 94080
WELLS, JA
;
FERRARI, E
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC,DEPT MOLEC BIOL,SAN FRANCISCO,CA 94080
FERRARI, E
;
HENNER, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC,DEPT MOLEC BIOL,SAN FRANCISCO,CA 94080
HENNER, DJ
;
ESTELL, DA
论文数:
0
引用数:
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h-index:
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机构:
GENENTECH INC,DEPT MOLEC BIOL,SAN FRANCISCO,CA 94080
ESTELL, DA
;
CHEN, EY
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC,DEPT MOLEC BIOL,SAN FRANCISCO,CA 94080
CHEN, EY
.
NUCLEIC ACIDS RESEARCH,
1983,
11
(22)
:7911
-7925
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