POLYCHLORINATED-BIPHENYLS MODULATE PROTOONCOGENE EXPRESSION IN CHANG LIVER-CELLS

被引：6

作者：

HORNHARDT, S ^{[1
]}

JENKE, HS ^{[1
]}

MICHEL, G ^{[1
]}

机构：

[1] GSF,FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,ZELLCHEM ABT,D-85758 OBERSCHLEISSHEIM,GERMANY

来源：

FEBS LETTERS | 1994年 / 339卷 / 1-2期

关键词：

PCB; PROTOONCOGENE EXPRESSION; C-ERBA; C-ERBB; C-RAF; TUMOR PROMOTER;

D O I：

10.1016/0014-5793(94)80412-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Chang liver cells we studied the influence of polychlorinated biphenyls (PCB) on the expression of different protooncogenes. In cells incubated with medium supplemented with PCB we observed an early effect after 3 h on c-erbA and c-erbB RNA level. This reduction of RNA was due to a delayed transcriptional activation of the genes. The PCB congener 3,3',4,4',5-pentachlorobiphenyl (5-CB) in a 1,000-fold lower concentration influenced protooncogene expression in the same manner. In contrast c-raf RNA level increased transiently after 24 h. The fact that persistent chemicals like PCB interfere with protooncogene expression is particularly interesting in view of their tumor promoting activity.

引用

页码：185 / 188

页数：4

共 23 条

[1] VIRAL ONCOGENES [J].

BISHOP, JM .

CELL, 1985, 42 (01) :23-38

[2] 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN CAUSES INCREASES IN EXPRESSION OF C-ERB-A AND LEVELS OF PROTEIN-TYROSINE KINASES IN SELECTED TISSUES OF RESPONSIVE MOUSE STRAINS [J].

BOMBICK, DW ;

JANKUN, J ;

TULLIS, K ;

MATSUMURA, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4128-4132

[3] CRITICAL ROLE PLAYED BY THYROID-HORMONE IN INDUCTION OF NEOPLASTIC TRANSFORMATION BY CHEMICAL CARCINOGENS IN TISSUE-CULTURE [J].

BOREK, C ;

GUERNSEY, DL ;

ONG, A ;

EDELMAN, IS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (18) :5749-5752

[4] POLYCHLORINATED-BIPHENYLS, CLASSIFIED AS EITHER PHENOBARBITAL-TYPE OR 3-METHYLCHOLANTHRENE-TYPE INDUCERS OF CYTOCHROME-P-450, ARE BOTH HEPATIC TUMOR PROMOTERS IN DIETHYLNITROSAMINE-INITIATED RATS [J].

BUCHMANN, A ;

KUNZ, W ;

WOLF, CR ;

OESCH, F ;

ROBERTSON, LW .

CANCER LETTERS, 1986, 32 (03) :243-253

[5] ONCOGENES AND SIGNAL TRANSDUCTION [J].

CANTLEY, LC ;

AUGER, KR ;

CARPENTER, C ;

DUCKWORTH, B ;

GRAZIANI, A ;

KAPELLER, R ;

SOLTOFF, S .

CELL, 1991, 64 (02) :281-302

[6] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[7] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[8] TUMOR PROMOTERS AND CELL-TRANSFORMATION [J].

DIAMOND, L .

PHARMACOLOGY & THERAPEUTICS, 1984, 26 (01) :89-145

[9] STIMULATION OF 3T3 CELLS INDUCES TRANSCRIPTION OF THE C-FOS PROTO-ONCOGENE [J].

GREENBERG, ME ;

ZIFF, EB .

NATURE, 1984, 311 (5985) :433-438

[10] PROTOONCOGENE EXPRESSION IN RAT-LIVER BY POLYCHLORINATED-BIPHENYLS (PCB) [J].

JENKE, HS ;

MICHEL, G ;

HORNHARDT, S ;

BERNDT, J .

XENOBIOTICA, 1991, 21 (07) :945-960

← 1 2 3 →