A PROTEIN-KINASE INHIBITOR, H-7, INHIBITS THE DEVELOPMENT OF TOLERANCE TO OPIOID ANTINOCICEPTION

被引：50

作者：

NARITA, M

FENG, YZ

MAKIMURA, M

HOSKINS, B

HO, IK

机构：

[1] Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216-4505

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 271卷 / 2-3期

关键词：

OPIOID TOLERANCE; MORPHINE; BUTORPHANOL; PROTEIN KINASE A; PROTEIN KINASE C;

D O I：

10.1016/0014-2999(94)90817-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To investigate the effect of a protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), on the development of tolerance to antinociception induced by morphine (mu-opioid receptor agonist) and butorphanol (mu/delta/kappa-mixed opioid receptor agonist), rats were infused i.c.v. with morphine, butorphanol and H-7 through osmotic minipumps for 3 days. Concomitant infusion of H-7 dose dependently inhibited the development of tolerance to i.c.v. morphine- and butorphanol-induced antinociception. These results suggest that protein kinases may play an important role in the development of opioid tolerance.

引用

页码：543 / 545

页数：3

共 8 条

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[2]

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