RENIN-ALDOSTERONE RELATIONSHIPS IN PREGNANCY-INDUCED HYPERTENSION

被引：71

作者：

BROWN, MA

ZAMMIT, VC

MITAR, DA

WHITWORTH, JA

机构：

[1] Department of Renal Medicine and School of Medicine, University of New South Wales, Sydney, NSW, St. George Hospital

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1992年 / 5卷 / 06期

关键词：

RENIN; ALDOSTERONE; ANGIOTENSIN-II; PREGNANCY; ADRENAL GLANDS; PREGNANCY-INDUCED HYPERTENSION;

D O I：

10.1093/ajh/5.6.366

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The relationship between plasma renin (PRC) and aldosterone (PAC) concentrations was determined in 83 normal third trimester pregnant women (P), 50 women with pregnancy-induced hypertension (PIH), and 80 age-matched nonpregnant women not taking oral contraceptives (NP). Normal pregnant women had a slightly higher 24-h urine sodium: creatinine ratio than the other groups (P < .001) (NP: 10 +/- 4 v P: 15 +/- 8 v PIH: 12 +/- 7; mean +/- SD). Both PRC and PAC were higher in normal pregnant women as was the ratio PAC:PRC [normal pregnant 195 (158 to 337) v nonpregnant 130 (101 to 209), median (interquartile range); P < .001]. This was accompanied by a slightly reduced slope (sensitivity) of the logPRC-logPAC relationship in normal pregnant women (P < .05). Women with PIH had reduced PRC and PAC compared with normal pregnant women but a two-fold greater increase in PAC:PRC ratio [PIH 411 (277 to 598) v normal pregnancy 195 (158 to 337), P < .001], with a rise in the slope (sensitivity) of the logPRC-logPAC relationship in women with PIH (P < .001). Thus there is proportionately greater aldosterone release in the third trimester of normal pregnancy than in nonpregnant women. This preferential increase in aldosterone may be due to altered adrenal sensitivity to angiotensin II or may reflect enhanced nonangiotensin stimulation of aldosterone during pregnancy. Women with PIH have reduced PRC and PAC but relatively greater stimulation of aldosterone than normal pregnant women, possibly due to enhanced sensitivity of the adrenal glands to angiotensin II.

引用

页码：366 / 371

页数：6

共 38 条

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