CHRONIC ETHANOL TREATMENT DIFFERENTIALLY REGULATES NMDA RECEPTOR SUBUNIT MESSENGER-RNA EXPRESSION IN RAT-BRAIN

被引:147
作者
FOLLESA, P [1 ]
TICKU, MK [1 ]
机构
[1] UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284
来源
MOLECULAR BRAIN RESEARCH | 1995年 / 29卷 / 01期
关键词
NMDA RECEPTOR SUBUNIT MESSENGER-RNA LEVEL; CHRONIC ETHANOL TREATMENT; UP-REGULATION;
D O I
10.1016/0169-328X(94)00235-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous studies have implicated the N-methyl-D-aspartate receptor (NMDAR) complex in the physical dependence and withdrawal effects of chronic ethanol administration. In this study, we examined the effect of chronic ethanol administration and ethanol withdrawal on the NMDAR subunit R1, R2A, R2B, and R2C mRNA levels in rat hippocampus, cerebral cortex, and cerebellum. Using the RNase protection assay, we compared the levels of the NMDAR subunits mRNAs in ethanol-treated and control rats. Our results indicate that chronic ethanol administration and ethanol withdrawal do not change the NMDAR R1 subunit mRNA levels in cerebral cortex, hippocampus, or cerebellum at any time point. In contrast, 9 h after the last ethanol administration the R2A and R2B mRNA subunits were elevated by approximate to 40% in cerebral cortex, and approximate to 30% in hippocampus with respect to the levels in control animals. At 48 h the mRNA levels returned to the control levels. The chronic ethanol treatment did not alter R1, R2A, and R2C subunit mRNA levels in cerebellum. Our results demonstrate that chronic ethanol administration produces a differential regulation of the genes encoding the various subunits of the NMDAR.
引用
收藏
页码:99 / 106
页数:8
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