EFFECT OF SELF-REINFORCED POLYGLYCOLIDE MEMBRANES ON CORTICAL BONE - AN EXPERIMENTAL-STUDY ON RATS

被引：18

作者：

ASHAMMAKHI, N ^{[1
]}

MAKELA, EA ^{[1
]}

VIHTONEN, K ^{[1
]}

ROKKANEN, P ^{[1
]}

TORMALA, P ^{[1
]}

机构：

[1] TAMPERE UNIV TECHNOL,BIOMAT LAB,TAMPERE,FINLAND

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1995年 / 29卷 / 06期

关键词：

D O I：

10.1002/jbm.820290603

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A self-reinforced polyglycolide (SR-PGA) membrane has been developed recently by our research group and testing of it begun. To study the behavior of this membrane and its effect on cortical bone, 93 Wistar rats were operated on. SR-PGA membrane was applied around the rats' femoral diaphyses, either over the periosteum or directly over the bone, after periosteal stripping. In a control group no membrane was applied, but the femoral periosteum was stripped away. The rats were sacrificed 1, 3, 6, 12, 24, and 30 weeks postoperatively. Radiology, histology, oxytetracycline fluorescence labeling, microradiography, and planimetry were used to determine the outcome. A fibrous tissue capsule had formed around and replaced the membrane. SR-PGA membrane had a positive effect on new bone formation. Callus was frequently seen proximally and distally to the implant. Periosteal thickening occurred whether or not SR-PGA membrane was used. PGA fibers decreased in number and diameter continuously until they vanished by 30 weeks. No infections or adverse reactions were encountered. Accordingly, SR-PGA membrane is considered to be biocompatible and applicable in the treatment of cortical bone lesions such as comminuted fractures and defects. (C) 1995 John Wiley & Sons, Inc.

引用

页码：687 / 694

页数：8

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