CHARACTERIZATION OF TYPE-I RECEPTORS FOR TRANSFORMING GROWTH-FACTOR-BETA AND ACTIVIN

被引：517

作者：

TENDIJKE, P

YAMASHITA, H

ICHIJO, H

FRANZEN, P

LAIHO, M

MIYAZONO, K

HELDIN, CH

机构：

[1] LUDWIG INST CANC RES,BOX 595 BIOMED CTR,S-75124 UPPSALA,SWEDEN

[2] UNIV HELSINKI,DEPT VIROL,SF-00014 HELSINKI,FINLAND

来源：

SCIENCE | 1994年 / 264卷 / 5155期

关键词：

D O I：

10.1126/science.8140412

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transforming growth factor-beta (TGF-beta) and activin exert their effects by binding to heteromeric complexes of type I and type II receptors. The type II receptors for TGF-beta and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is described here. ALK-5 has been shown to be a functional TGF-beta type I receptor. A systematic analysis revealed that most ALKs formed heteromeric complexes with the type II receptors for TGF-beta and activin after overexpression in COS cells; however, among the six ALKs, only ALK-5 was a functional TGF-beta type I receptor for activation of plasminogen activator inhibitor-1, and only ALK-2 and ALK-4 bound activin with high affinity.

引用

页码：101 / 104

页数：4

共 29 条

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