IN-VITRO ACTIVITY OF A NEW CARBAPENEM ANTIBIOTIC, BO-2727, WITH POTENT ANTIPSEUDOMONAL ACTIVITY

被引：41

作者：

NAKAGAWA, S ^{[1
]}

HASHIZUME, T ^{[1
]}

MATSUDA, K ^{[1
]}

SANADA, M ^{[1
]}

OKAMOTO, O ^{[1
]}

FUKATSU, H ^{[1
]}

TANAKA, N ^{[1
]}

机构：

[1] BANYU PHARMACEUT CO LTD,TSUKUBA RES INST,TSUKUBA,IBARAKI 30033,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 12期

关键词：

D O I：

10.1128/AAC.37.12.2756

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

BO-2727, a new l-beta-methyl-carbapenem, was active at concentrations of 6.25 mu g/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenern-resistant (MICs, greater than or equal to 12.5 mu g/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I.

引用

页码：2756 / 2759

页数：4

共 14 条

[1] CHARACTERIZATION OF BETA-LACTAMASES [J].

BUSH, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (03) :259-263

[2]

KAHAN FM, 1983, J ANTIMICROB CHEMOTH, V12, P1

[3] ANTI-BACTERIAL ACTIVITIES OF A NEW STABILIZED THIENAMYCIN, N-FORMIMIDOYL THIENAMYCIN, IN COMPARISON WITH OTHER ANTIBIOTICS [J].

KESADO, T ;

HASHIZUME, T ;

ASAHI, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 17 (06) :912-917

[4] MK0787 (N-FORMIMIDOYL THIENAMYCIN) - EVALUATION OF INVITRO AND INVIVO ACTIVITIES [J].

KROPP, H ;

SUNDELOF, JG ;

KAHAN, JS ;

KAHAN, FM ;

BIRNBAUM, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 17 (06) :993-1000

[5]

KROPP H, 1983, 23RD INT C ANT AG CH

[6] CROSS-RESISTANCE TO MEROPENEM, CEPHEMS, AND QUINOLONES IN PSEUDOMONAS-AERUGINOSA [J].

MASUDA, N ;

OHYA, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (09) :1847-1851

[7] INVITRO ACTIVITY AGAINST AEROBIC AND ANAEROBIC GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA AND BETA-LACTAMASE STABILITY OF RS-533, A NOVEL CARBAPENEM [J].

NEU, HC ;

CHIN, NX ;

SAHA, G ;

LABTHAVIKUL, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (06) :828-834

[8] INVITRO ACTIVITY AND BETA-LACTAMASE STABILITY OF A NEW CARBAPENEM, SM-7338 [J].

NEU, HC ;

NOVELLI, A ;

CHIN, NX .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (07) :1009-1018

[9] EMERGENCE OF RESISTANCE TO IMIPENEM DURING THERAPY FOR PSEUDOMONAS-AERUGINOSA INFECTIONS [J].

QUINN, JP ;

DUDEK, EJ ;

DIVINCENZO, CA ;

LUCKS, DA ;

LERNER, SA .

JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (02) :289-294

[10] PURIFICATION AND PROPERTIES OF AN INDUCIBLE CEPHALOSPORINASE FROM PSEUDOMONAS-MALTOPHILIA GN12873 [J].

SAINO, Y ;

INOUE, M ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 25 (03) :362-365

← 1 2 →