IN-VITRO ACTIVITY OF A NEW CARBAPENEM ANTIBIOTIC, BO-2727, WITH POTENT ANTIPSEUDOMONAL ACTIVITY

被引：41

作者：

NAKAGAWA, S ^{[1
]}

HASHIZUME, T ^{[1
]}

MATSUDA, K ^{[1
]}

SANADA, M ^{[1
]}

OKAMOTO, O ^{[1
]}

FUKATSU, H ^{[1
]}

TANAKA, N ^{[1
]}

机构：

[1] BANYU PHARMACEUT CO LTD,TSUKUBA RES INST,TSUKUBA,IBARAKI 30033,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 12期

关键词：

D O I：

10.1128/AAC.37.12.2756

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

BO-2727, a new l-beta-methyl-carbapenem, was active at concentrations of 6.25 mu g/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenern-resistant (MICs, greater than or equal to 12.5 mu g/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I.

引用

页码：2756 / 2759

页数：4

共 14 条

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