REOXYGENATION INJURY AND ANTIOXIDANT PROTECTION - A TALE OF 2 PARADOXES

被引:75
作者
GUTTERIDGE, JMC
HALLIWELL, B
机构
[1] OKLAHOMA MED RES FDN, OKLAHOMA CITY, OK 73104 USA
[2] PULM MED DIV, SACRAMENTO, CA 95817 USA
关键词
D O I
10.1016/0003-9861(90)90635-C
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Under certain circumstances, added antioxidants can protect tissues against reoxygenation injury after ischemia. Yet reperfusing blood carries many antioxidants with it. The implications of this "antioxidant paradox" are discussed. © 1990.
引用
收藏
页码:223 / 226
页数:4
相关论文
共 64 条
[31]  
GUTTERIDGE JMC, 1987, LIFE CHEM REPORTS, V4, P113
[32]   THE ANTIOXIDANTS OF HUMAN EXTRACELLULAR FLUIDS [J].
HALLIWELL, B ;
GUTTERIDGE, JMC .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 280 (01) :1-8
[33]   SUPEROXIDE, IRON, VASCULAR ENDOTHELIUM AND REPERFUSION INJURY [J].
HALLIWELL, B .
FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 5 (06) :315-318
[34]  
HALLIWELL B, 1990, METHOD ENZYMOL, V186, P1
[36]   OXIDANTS AND HUMAN-DISEASE - SOME NEW CONCEPTS [J].
HALLIWELL, B .
FASEB JOURNAL, 1987, 1 (05) :358-364
[38]   ABRUPT REOXYGENATION OF ANOXIC POTASSIUM-ARRESTED PERFUSED RAT-HEART - STUDY OF MYOCARDIAL ENZYME RELEASE [J].
HEARSE, DJ ;
HUMPHREY, SM ;
CHAIN, EB .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1973, 5 (04) :395-407
[39]   NITRIC-OXIDE - A CYTO-TOXIC ACTIVATED MACROPHAGE EFFECTOR MOLECULE [J].
HIBBS, JB ;
TAINTOR, RR ;
VAVRIN, Z ;
RACHLIN, EM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (01) :87-94
[40]   DNA DAMAGE AND OXYGEN RADICAL TOXICITY [J].
IMLAY, JA ;
LINN, S .
SCIENCE, 1988, 240 (4857) :1302-1309