EFFICACY OF LY233053, A COMPETITIVE GLUTAMATE ANTAGONIST, IN EXPERIMENTAL CENTRAL-NERVOUS-SYSTEM ISCHEMIA

被引：16

作者：

MADDEN, KP ^{[1
]}

CLARK, WM ^{[1
]}

KOCHHAR, A ^{[1
]}

ZIVIN, JA ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT NEUROSCI M024,LA JOLLA,CA 92093

来源：

JOURNAL OF NEUROSURGERY | 1992年 / 76卷 / 01期

关键词：

ISCHEMIA; GLUTAMATE ANTAGONIST; AMINO ACID RECEPTOR; RABBIT;

D O I：

10.3171/jns.1992.76.1.0106

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Antagonists of excitatory amino acids appear to serve a neuroprotective role during ischemic conditions in a variety of in vivo and in vitro models. The usefulness of such agents in the clinical setting, however, may be limited by poor central nervous system (CNS) entry and intolerable side effects. The authors report high efficacy in reducing neurological damage and relatively limited side effects of LY233053, a novel competitive glutamate antagonist, in two models of experimental CNS ischemia in the rabbit.

引用

页码：106 / 110

页数：5

共 15 条

[1] N-METHYL-D-ASPARTATE ANTAGONISTS - READY FOR CLINICAL-TRIAL IN BRAIN ISCHEMIA [J].

ALBERS, GW ;

GOLDBERG, MP ;

CHOI, DW .

ANNALS OF NEUROLOGY, 1989, 25 (04) :398-403

[2] THE N-METHYL-D-ASPARTATE ANTAGONISTS CGS-19755 AND CPP REDUCE ISCHEMIC BRAIN-DAMAGE IN GERBILS [J].

BOAST, CA ;

GERHARDT, SC ;

PASTOR, G ;

LEHMANN, J ;

ETIENNE, PE ;

LIEBMAN, JM .

BRAIN RESEARCH, 1988, 442 (02) :345-348

[3]

BOAST CA, 1987, EXCITATORY AMINO ACI, P249

[4]

FERKANY JW, 1989, J PHARMACOL EXP THER, V250, P100

[5] CGS-19755, A COMPETITIVE NMDA RECEPTOR ANTAGONIST, REDUCES CALCIUM-CALMODULIN BINDING AND IMPROVES OUTCOME AFTER GLOBAL CEREBRAL-ISCHEMIA [J].

GROTTA, JC ;

PICONE, CM ;

OSTROW, PT ;

STRONG, RA ;

EARLS, RM ;

YAO, LP ;

RHOADES, HM ;

DEDMAN, JR .

ANNALS OF NEUROLOGY, 1990, 27 (06) :612-619

[6] GLUTAMATE ANTAGONIST THERAPY REDUCES NEUROLOGIC DEFICITS PRODUCED BY FOCAL CENTRAL NERVOUS-SYSTEM ISCHEMIA [J].

KOCHHAR, A ;

ZIVIN, JA ;

LYDEN, PD ;

MAZZARELLA, V .

ARCHIVES OF NEUROLOGY, 1988, 45 (02) :148-153

[7] THE SPECIFIC NMDA RECEPTOR ANTAGONIST AP-7 ATTENUATES FOCAL ISCHEMIC BRAIN INJURY [J].

ROMAN, R ;

BARTKOWSKI, H ;

SIMON, R .

NEUROSCIENCE LETTERS, 1989, 104 (1-2) :19-24

[8] GLUTAMATE AND THE PATHOPHYSIOLOGY OF HYPOXIC ISCHEMIC BRAIN-DAMAGE [J].

ROTHMAN, SM ;

OLNEY, JW .

ANNALS OF NEUROLOGY, 1986, 19 (02) :105-111

[9]

SCHOEPP DD, 1990, J PHARMACOL EXP THER, V255, P1301

[10] N-METHYL-D-ASPARTATE ANTAGONIST REDUCES STROKE SIZE AND REGIONAL GLUCOSE-METABOLISM [J].

SIMON, R ;

SHIRAISHI, K .

ANNALS OF NEUROLOGY, 1990, 27 (06) :606-611

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