INVESTIGATION OF THE POTENTIAL ROLE OF GENETIC IMPRINTING IN GILLES-DE-LA-TOURETTE SYNDROME

Genetic imprinting refers to the phenomenon whereby the precise expression of a specific trait (or disease) may depend on the sex of the transmitting parent. The purpose of the present project was to investigate the possibility for the involvement of genetic imprinting in Tourette syndrome (TS), a disease of the central nervous system in which many cases show evidence of an autosomal dominant mode of inheritance. The justification for the study arose hom the noted variable expression of the associated symptoms in TS. Through the method of chart review, information regarding sex of the transmitting parent, age of onset of motor ties, as well as associated symptoms, was gathered from patients with a clear family history of TS consistent with autosomal dominant mode of transmission. No evidence was found for genetic imprinting in TS. The potential criticisms and implications of this finding are discussed. (C) 1994 Wiley-Liss, Inc.