REGIONAL DIFFERENCE OF HIGH VOLTAGE-ACTIVATED CA2+ CHANNELS IN RAT CNS NEURONS

被引：45

作者：

ISHIBASHI, H ^{[1
]}

RHEE, JS ^{[1
]}

AKAIKE, N ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT PHYSIOL,FUKUOKA 81282,JAPAN

来源：

NEUROREPORT | 1995年 / 6卷 / 12期

关键词：

CNS NEURONS; REGIONAL DIFFERENCE; HVA CA2+ CHANNELS; OMEGA-CONOTOXIN-MVIIC; OMEGA-AGATOXIN-IVA; OMEGA-CONOTOXIN-GVIA; NICARDIPINE;

D O I：

10.1097/00001756-199508000-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE diversity of high voltage-activated (HVA) Ca2+ channels in rat CNS neurones was investigated with the nystatin perforated patch recording configuration. The neurones were freshly dissociated from rat substantia nigra, ventromedial hypothalamus, tuberomammillary nucleus, nucleus tractus solitarius, hippocampal CA1 region and cerebellum. Five different types of HVA Ca2+ channels were distinguished pharmacologically; dihydropyridine sensitive L-type, omega-conotoxin-GVIA sensitive N-type, omega-agatoxin-IVA sensitive P-type, omega-conotoxin-MVIIC sensitive Q-type, and R-type which is insensitive to these organic Ca antagonists. The results showed clearly that the five subtypes of HVA Ca2+ channels differ considerably in their distribution among various CNS regions.

引用

页码：1621 / 1624

页数：4

共 15 条

[1] NYSTATIN PERFORATED-PATCH RECORDING AND ITS APPLICATIONS TO ANALYSES OF INTRACELLULAR MECHANISMS [J].