EVIDENCE FOR THE PRODUCTION OF HIGH AMOUNTS OF INTERLEUKIN-6 IN THE PERITONEAL-CAVITY OF PATIENTS WITH ASCITES

被引：35

作者：

ANDUS, T ^{[1
]}

GROSS, V ^{[1
]}

HOLSTEGE, A ^{[1
]}

WEBER, M ^{[1
]}

OTT, M ^{[1
]}

GEROK, W ^{[1
]}

SCHOLMERICH, J ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT INTERNAL MED,W-7800 FREIBURG,GERMANY

来源：

JOURNAL OF HEPATOLOGY | 1992年 / 15卷 / 03期

关键词：

INTERLEUKIN-6; ASCITES; CIRRHOSIS; MALIGNANT ASCITES;

D O I：

10.1016/0168-8278(92)90072-W

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The ascites and serum concentrations of interleukin-6 (IL-6) and interleukin-I (IL-1) were determined in 21 patients with hepatic ascites and in 9 patients with malignancy-associated ascites. There was no evidence for bacterial peritonitis in any patients. All ascites samples contained high amounts of immunoreactive IL-6 [ hepatic ascites 1730 +/- 2130 pg/ml (mean +/- SD), 1160 pg/ml (median); malignant ascites 4020 +/- 1510 pg/ml (mean), 3820 pg/ml (median)] but no IL-1. The mean ascites to serum ratios of IL-6 were 96 (median 49) in patients with hepatic ascites and 587 (median 480) in patients with malignant ascites. Ascites IL-6 was biologically active as determined by the B9 cell bioassay. The results indicate that even in the absence of infection IL-6 is produced in high amounts in the peritoneal cavity of patients with hepatic or malignant ascites.

引用

页码：378 / 381

页数：4

共 14 条

[11]

SCHINDLER R, 1990, BLOOD, V75, P40

[12] PERIPHERAL ARTERIAL VASODILATION HYPOTHESIS - A PROPOSAL FOR THE INITIATION OF RENAL SODIUM AND WATER-RETENTION IN CIRRHOSIS [J].

SCHRIER, RW ;

ARROYO, V ;

BERNARDI, M ;

EPSTEIN, M ;

HENRIKSEN, JH ;

RODES, J .

HEPATOLOGY, 1988, 8 (05) :1151-1157

[13]

TARAO K, 1977, GASTROENTEROLOGY, V73, P539

[14] PERITONEOVENOUS SHUNTING IN THE TREATMENT OF ASCITES - COMPLICATIONS AND THEIR MANAGEMENT [J].

VOLK, BA ;

SCHOLMERICH, J ;

WILMS, H ;

KOTTGEN, E ;

WITZ, G ;

BILLMANN, P ;

HOPPESEYLER, P ;

GEROK, W .

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1985, 110 (44) :1685-1691

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