THE DROSOPHILA-TUMOROUS-LETHAL HEMATOPOIETIC ONCOGENE IS A DOMINANT MUTATION IN THE HOPSCOTCH LOCUS

被引：130

作者：

HANRATTY, WP

DEAROLF, CR

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,ROOM JF 209,44 BINNEY ST,BOSTON,MA 02115

[2] UNIV SO MISSISSIPPI,DEPT BIOL SCI,HATTIESBURG,MS 39406

[3] HARVARD UNIV,SCH MED,DEPT RADIAT ONCOL,BOSTON,MA 02115

来源：

MOLECULAR & GENERAL GENETICS | 1993年 / 238卷 / 1-2期

关键词：

DROSOPHILA-MELANOGASTER; TUMOROUS-LETHAL GENE; HOPSCOTCH GENE; HEMATOPOIESIS;

D O I：

10.1007/BF00279527

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

引用

页码：33 / 37

页数：5

共 22 条

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