THE DROSOPHILA-TUMOROUS-LETHAL HEMATOPOIETIC ONCOGENE IS A DOMINANT MUTATION IN THE HOPSCOTCH LOCUS

被引：130

作者：

HANRATTY, WP

DEAROLF, CR

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,ROOM JF 209,44 BINNEY ST,BOSTON,MA 02115

[2] UNIV SO MISSISSIPPI,DEPT BIOL SCI,HATTIESBURG,MS 39406

[3] HARVARD UNIV,SCH MED,DEPT RADIAT ONCOL,BOSTON,MA 02115

来源：

MOLECULAR & GENERAL GENETICS | 1993年 / 238卷 / 1-2期

关键词：

DROSOPHILA-MELANOGASTER; TUMOROUS-LETHAL GENE; HOPSCOTCH GENE; HEMATOPOIESIS;

D O I：

10.1007/BF00279527

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

引用

页码：33 / 37

页数：5

共 22 条

[11] CELLULAR IMMUNE COMPETENCE OF A DROSOPHILA MUTANT WITH NEOPLASTIC HEMATOPOIETIC ORGANS
NAPPI, AJ
KMIECIK, J
SILVERS, M
[J]. JOURNAL OF INVERTEBRATE PATHOLOGY, 1984, 44 (02) : 220 - 227
[12] CELL-SURFACE CHANGES ASSOCIATED WITH CELLULAR IMMUNE-REACTIONS IN DROSOPHILA
NAPPI, AJ
SILVERS, M
[J]. SCIENCE, 1984, 225 (4667) : 1166 - 1168
[13] L(1)HOPSCOTCH, A LARVAL PUPAL ZYGOTIC LETHAL WITH A SPECIFIC MATERNAL EFFECT ON SEGMENTATION IN DROSOPHILA
PERRIMON, N
MAHOWALD, AP
[J]. DEVELOPMENTAL BIOLOGY, 1986, 118 (01) : 28 - 41
[14] RIZKI TM, 1978, GENETICS BIOL DROS B, V2, P398
[15] REDUCED NM23 AWD PROTEIN IN TUMOR-METASTASIS AND ABERRANT DROSOPHILA DEVELOPMENT
ROSENGARD, AM
KRUTZSCH, HC
SHEARN, A
BIGGS, JR
BARKER, E
MARGULIES, IMK
KING, CR
LIOTTA, LA
STEEG, PS
[J]. NATURE, 1989, 342 (6246) : 177 - 180
[16] PROTOONCOGENES IN DROSOPHILA-MELANOGASTER
SHILO, BZ
[J]. TRENDS IN GENETICS, 1987, 3 (03) : 69 - 72
[17] ALTERATIONS IN THE PRODUCTION OF HEMOCYTES DUE TO A NEOPLASTIC MUTATION OF DROSOPHILA-MELANOGASTER
SILVERS, M
HANRATTY, WP
[J]. JOURNAL OF INVERTEBRATE PATHOLOGY, 1984, 44 (03) : 324 - 328
[18] Sparrow J.C., 1978, P277
[19] RECOVERY AND PRELIMINARY CHARACTERIZATION OF X-CHROMOSOME MUTANTS AFFECTING IMAGINAL DISKS OF DROSOPHILA-MELANOGASTER
STEWART, M
MURPHY, C
FRISTROM, JW
[J]. DEVELOPMENTAL BIOLOGY, 1972, 27 (01) : 71 - &
[20] LETHAL(1) ABERRANT IMMUNE-RESPONSE MUTATIONS LEADING TO MELANOTIC TUMOR-FORMATION IN DROSOPHILA-MELANOGASTER
WATSON, KL
JOHNSON, TK
DENELL, RE
[J]. DEVELOPMENTAL GENETICS, 1991, 12 (03): : 173 - 187

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