THE EXPRESSION OF A NEURONAL NUCLEAR ANTIGEN (RI) RECOGNIZED BY THE HUMAN ANTI-RI AUTOANTIBODY IN THE DEVELOPING RAT NERVOUS-SYSTEM

被引：12

作者：

FUEYO, J

FERRER, I

VALLDEORIOLA, F

GRAUS, F

机构：

[1] HOSP CLIN BARCELONA, SERV NEUROL, VILLARROEL 170, E-08036 BARCELONA, SPAIN

[2] HOSP MARE DEU ESPERANCA, BARCELONA, SPAIN

[3] HOSP LLOBREGAT, HOSP PRINCIPES ESPANA, NEUROPATHOL UNIT, BARCELONA, SPAIN

来源：

NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期

关键词：

AUTOANTIBODY; PARANEOPLASTIC DISEASE; NEURONAL DEVELOPMENT; RETINA; NEURONAL ANTIGEN; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0304-3940(93)90580-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Anti-Ri is a human autoantibody that recognizes a neuronal nuclear antigen (Ri) of unknown function. To ascertain the possible role of the Ri antigen in neuronal development, we analysed the pattern of the anti-Ri immunoreactivity in the developing rat nervous system. Neurons of the retina, except the photoreceptors, and central but not peripheral nervous system were anti-Ri-positive. The intensity of the immunoreactivity followed the sequence of neuronal maturation. Germinal cells of the periventricular layer and migrating neuroblasts in the intermediate zone were Ri-negative. These data suggest Ri antigen may play a role in the postmigratory maturation of neurons of the CNS.

引用

页码：141 / 144

页数：4

共 13 条

[1] DEVELOPMENT OF RETINA OF ALBINO RAT [J].