POTENTIAL ANTIMALARIALS .13. MONO-MANNICH BASES OF 4-[7-CHLORO (AND 7-TRIFLUOROMETHYL)QUINOLIN-4-YLAMINO] AND 4-(7-BROMO-1,5-NAPHTHYRIDIN-4-YLAMINO)- 3-METHYLPHENOL

被引：7

作者：

BARLIN, GB

JIRAVINYU, C

机构：

[1] Division of Neuroscience, John Curtin School of Medical Research, Australian National University

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1991年 / 44卷 / 01期

关键词：

D O I：

10.1071/CH9910151

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of di-Mannich bases derived from 4-[7-chloro (and 7-trifluoromethyl)quinolin-4-ylamino] and 4-(7-bromo-1,5-naphthyridin-4-ylamino)-3-methylphenol are reported. In tests for antimalarial activity against the FCQ-27 (chlorquine-sensitive) and K-1 (chloroquine-resistant) isolates of Plasmodium falciparum in vitro, the 3-methylphenols were shown to be less active than their demethyl analogues reported previously.

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页码：151 / 156

页数：6

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