ANTI-SEDATIVE AND ANTI-CATALEPTIC PROPERTIES OF NCS-382, A GAMMA-HYDROXYBUTYRATE RECEPTOR ANTAGONIST

被引：56

作者：

SCHMIDT, C ^{[1
]}

GOBAILLE, S ^{[1
]}

HECHLER, V ^{[1
]}

SCHMITT, M ^{[1
]}

BOURGUIGNON, JJ ^{[1
]}

MAITRE, M ^{[1
]}

机构：

[1] CNRS,CTR NEUROCHIM,5 RUE BLAISE PASCAL,F-67084 STRASBOURG,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 203卷 / 03期

关键词：

GAMMA-HYDROXYBUTYRATE RECEPTORS; GAMMA-HYDROXYBUTYRATE RECEPTOR ANTAGONISTS; SEDATIVE ANESTHETIC EFFECTS; BRAIN (RAT); NCS-382; CATALEPSY; NEUROLEPTICS;

D O I：

10.1016/0014-2999(91)90896-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

NCS-382 possesses antagonistic properties at gamma-hydroxybutyrate receptor sites. Its effect on the sedative/cataleptic behaviour observed in rats after gamma-hydroxybutyrate administration was investigated. NCS-382 diminished, in a dose-dependent manner, the sedative and/or cataleptic effects of gamma-hydroxybutyrate, as revealed by a variety of sensorimotor tests. These results indicate that the well-known sedative/anaesthetic effects induced by gamma-hydroxybutyrate administration are provoked via stimulation of a specific class(es) of gamma-hydroxybutyrate receptors which exist in the rat brain and which could mediate a local stimulation of opiate synthesis and release.

引用

页码：393 / 397

页数：5

共 27 条

[21] GAMMA HYDROXYBUTYRATE [J].

SNEAD, OC .

LIFE SCIENCES, 1977, 20 (12) :1935-1943

[22]

SNEAD OC, 1988, EPILEPSIA, V29, P361

[23]

SNEAD OC, 1984, BIOCHEM PHARMACOL, V33, P2587

[24] GAMMA-HYDROXYBUTYRATE STIMULATION OF THE FORMATION OF CYCLIC-GMP AND INOSITOL PHOSPHATES IN RAT HIPPOCAMPAL SLICES [J].

VAYER, P ;

MAITRE, M .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (05) :1382-1387

[25] GAMMA-HYDROXYBUTYRATE, A POSSIBLE NEUROTRANSMITTER [J].

VAYER, P ;

MANDEL, P ;

MAITRE, M .

LIFE SCIENCES, 1987, 41 (13) :1547-1557

[26] IS THE ANTICONVULSANT MECHANISM OF VALPROATE LINKED TO ITS INTERACTION WITH THE CEREBRAL GAMMA-HYDROXYBUTYRATE SYSTEM [J].

VAYER, P ;

CASH, CD ;

MAITRE, M .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (04) :127-129

[27]

WALTERS JR, 1973, J PHARMACOL EXP THER, V186, P630

← 1 2 3 →