INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN PROFILES IN HUMAN OVARIAN FOLLICULAR-FLUID CORRELATE WITH FOLLICULAR FUNCTIONAL STATUS

被引:123
作者
CATALDO, NA [1 ]
GIUDICE, LC [1 ]
机构
[1] STANFORD UNIV, MED CTR, DEPT GYNECOL & OBSTET, ROOM A342, STANFORD, CA 94305 USA
关键词
D O I
10.1210/jc.74.4.821
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The insulin-like growth factors (IGF), IGF-I and IGF-II, influence ovarian follicular development. The IGF binding proteins (IGFBPs) comprise at least six distinct species which may modulate IGF action. We examined IGFBP profiles in follicular fluid (FF) from developing human ovarian follicles with aromatase activity as well as from androgen-dominant, atretic follicles. Western ligand blot analysis of FF from both atretic and active follicles revealed the presence of IGFBP-3 and IGFBP-2, confirmed by immunoprecipitation with specific antiserum, as well as 28 kilodalton (kDa) and 24 kDa IGFBPs. In FF specimens obtained during the follicular phase, IGFBP-2 and the 28 kDa and 24 kDa species were present in 3-, 6-, and 19-fold higher amounts in atretic compared to healthy developing follicles, respectively, and were present in greater amounts in atretic FF than in serum. In atretic FF obtained during the luteal phase, lower levels of IGFBP-2 and the 28 and 24 kDa IGFBPs were seen than in atretic follicles in the follicular phase. IGFBP-3 levels were comparable in all types of follicles and in serum. The 28 kDa IGFBP is glycosylated, and its level varied in parallel with the 24 kDa IGFBP, suggesting that these are variants of the recently identified IGFBP-4. IGFBP-1 was not detectable by immunoprecipitation and ligand blotting of FF obtained during the follicular phase. These data suggest that one or more IGFBPs present in higher levels in FF from atretic compared to healthy, developing follicles may play an important role in folliculogenesis and follicular atresia.
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页码:821 / 829
页数:9
相关论文
共 46 条
[1]   OVARIAN GRANULOSA CELL-DERIVED INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS - MODULATORY ROLE OF FOLLICLE-STIMULATING-HORMONE [J].
ADASHI, EY ;
RESNICK, CE ;
HURWITZ, A ;
RICCIARELLI, E ;
HERNANDEZ, ER ;
ROSENFELD, RG .
ENDOCRINOLOGY, 1991, 128 (02) :754-760
[2]   POTENTIAL RELEVANCE OF INSULIN-LIKE GROWTH FACTOR-I TO OVARIAN PHYSIOLOGY - FROM BASIC SCIENCE TO CLINICAL-APPLICATION [J].
ADASHI, EY ;
RESNICK, CE ;
HERNANDEZ, ER ;
SVOBODA, ME ;
VANWYK, JJ .
SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 1989, 7 (01) :94-99
[3]  
ADASHI EY, 1991, 38TH ANN M SOC GYN I
[4]   INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN (IGF-BP) INHIBITION OF GRANULOSA-CELL FUNCTION - EFFECT ON CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE, DEOXYRIBONUCLEIC-ACID SYNTHESIS, AND COMPARISON WITH THE EFFECT OF AN IGF-I ANTIBODY [J].
BICSAK, TA ;
SHIMONAKA, M ;
MALKOWSKI, M ;
LING, N .
ENDOCRINOLOGY, 1990, 126 (04) :2184-2189
[5]   ANDROGENS AND PROGESTINS IN THE HUMAN OVARIAN FOLLICLE - DIFFERENCES IN THE EVOLUTION OF PREOVULATORY, HEALTHY NON-OVULATORY, AND ATRETIC FOLLICLES [J].
BRAILLY, S ;
GOUGEON, A ;
MILGROM, E ;
BOMSELHELMREICH, O ;
PAPIERNIK, E .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (01) :128-134
[6]  
CATALDO NA, 1991, 73RD ANN M END SOC W
[7]   DIFFERENTIAL-EFFECTS OF INSULIN-LIKE GROWTH-FACTOR (IGF)-I AND IGF-II ON THE EXPRESSION OF IGF BINDING-PROTEINS (IGFBPS) IN A RAT NEUROBLASTOMA CELL-LINE - ISOLATION AND CHARACTERIZATION OF 2 FORMS OF IGFBP-4 [J].
CEDA, GP ;
FIELDER, PJ ;
HENZEL, WJ ;
LOUIE, A ;
DONOVAN, SM ;
HOFFMAN, AR ;
ROSENFELD, RG .
ENDOCRINOLOGY, 1991, 128 (06) :2815-2824
[8]   CHARACTERIZATION OF AN INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP-4) PRODUCED BY THE B104 RAT NEURONAL CELL-LINE - CHEMICAL AND BIOLOGICAL PROPERTIES AND DIFFERENTIAL SYNTHESIS BY SUBLINES [J].
CHEUNG, PT ;
SMITH, EP ;
SHIMASAKI, S ;
LING, N ;
CHERNAUSEK, SD .
ENDOCRINOLOGY, 1991, 129 (02) :1006-1015
[9]   GROWTH-HORMONE INCREASES OVARIAN LEVELS OF IMMUNOREACTIVE SOMATOMEDIN-C INSULIN-LIKE GROWTH FACTOR-I INVIVO [J].
DAVOREN, JB ;
HSUEH, AJW .
ENDOCRINOLOGY, 1986, 118 (02) :888-890
[10]   A COMPARISON OF FOLLICULAR-FLUID LEVELS OF INSULIN-LIKE GROWTH FACTOR-I IN NORMAL DOMINANT AND COHORT FOLLICLES, POLYCYSTIC AND MULTICYSTIC OVARIES [J].
EDEN, JA ;
JONES, J ;
CARTER, GD ;
ALAGHBANDZADEH, J .
CLINICAL ENDOCRINOLOGY, 1988, 29 (03) :327-336