VASCULAR MALFORMATIONS AND EPILEPSY - CLINICAL CONSIDERATIONS AND BASIC MECHANISMS

被引：104

作者：

KRAEMER, DL

AWAD, IA

机构：

[1] Section of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut

来源：

EPILEPSIA | 1994年 / 35卷

关键词：

D O I：

10.1111/j.1528-1157.1994.tb05987.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vascular malformations (VMs) are associated with epilepsy. The natural history of the various VMs, clinical presentation, and tendency to provoke epilepsy determine treatment strategies. Investigations have probed the mechanisms of epileptogenesis associated with these lesions. Electrophysiologic changes are associated with epileptogenic cortex adjacent to VMs. Putative pathophysiologic mechanisms of epileptogenesis include neuronal cell loss, glial proliferation and abnormal glial physiology, altered neurotransmitter levels, free radical formation, and aberrant second messenger physiology.

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页码：S30 / S43

页数：14

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