THYROTROPIN-RELEASING-HORMONE SELECTIVELY DEPRESSES GLUTAMATE EXCITATION OF CEREBRAL CORTICAL-NEURONS

被引：86

作者：

RENAUD, LP

BLUME, HW

PITTMAN, QJ

LAMOUR, Y

TAN, AT

机构：

[1] Division of Neurology, Montreal General Hospital

来源：

SCIENCE | 1979年 / 205卷 / 4412期

关键词：

D O I：

10.1126/science.224461

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites. Copyright © 1979 AAAS.

引用

页码：1275 / 1277

页数：3

共 32 条

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