THYROTROPIN-RELEASING-HORMONE SELECTIVELY DEPRESSES GLUTAMATE EXCITATION OF CEREBRAL CORTICAL-NEURONS

被引：86

作者：

RENAUD, LP

BLUME, HW

PITTMAN, QJ

LAMOUR, Y

TAN, AT

机构：

[1] Division of Neurology, Montreal General Hospital

来源：

SCIENCE | 1979年 / 205卷 / 4412期

关键词：

D O I：

10.1126/science.224461

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites. Copyright © 1979 AAAS.

引用

页码：1275 / 1277

页数：3

共 32 条

[11] THYROTROPIN-RELEASING-HORMONE (TRH) - DISTRIBUTION IN HYPOTHALAMIC AND EXTRAHYPOTHALAMIC BRAIN-TISSUES OF MAMMALIAN AND SUBMAMMALIAN CHORDATES
JACKSON, IMD
REICHLIN, S
[J]. ENDOCRINOLOGY, 1974, 95 (03) : 854 - 862
[12] MECHANISM OF EXCITATION BY ACETYLCHOLINE IN CEREBRAL CORTEX
KRNJEVIC, K
PUMAIN, R
RENAUD, L
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1971, 215 (01): : 247 - &
[13] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[14] TRH - POSSIBLE MEDIATOR OF THERMOREGULATION
METCALF, G
[J]. NATURE, 1974, 252 (5481) : 310 - 311
[15] HYPOTHALAMIC POLYPEPTIDE RELEASING HORMONES - MODIFIERS OF NEURONAL-ACTIVITY
MOSS, RL
DUDLEY, CA
KELLY, MJ
[J]. NEUROPHARMACOLOGY, 1978, 17 (02) : 87 - 93
[16] EXCITATORY ACTION OF TRH ON SPINAL MOTONEURONS
NICOLL, RA
[J]. NATURE, 1977, 265 (5591) : 242 - 243
[17] DISTRIBUTION AND CONCENTRATION OF TRH IN RAT-BRAIN
OLIVER, C
ESKAY, RL
BENJONAT.N
PORTER, JC
[J]. ENDOCRINOLOGY, 1974, 95 (02) : 540 - 546
[18] PACHECO M, 1978, SOC NEUR ABSTR, V4, P412
[19] THYROTROPIN RELEASING HORMONE - ENHANCEMENT OF DOPA ACTIVITY IN THYROIDECTOMIZED RATS
PLOTNIKOFF, NP
PRANGE, AJ
BREESE, GR
WILSON, IC
[J]. LIFE SCIENCES, 1974, 14 (07) : 1271 - 1278
[20] THYROTROPIN RELEASING HORMONE - ANTAGONISM OF PENTOBARBITAL IN RODENTS
PRANGE, AJ
BREESE, GR
COTT, JM
MARTIN, BR
COOPER, BR
WILSON, IC
PLOTNIKOFF, NP
[J]. LIFE SCIENCES, 1974, 14 (03) : 447 - 455

← 1 2 3 4 →