SYNTHESIS OF THE C12-C26 FRAGMENT OF THE ACYLTETRONIC ACID IONOPHORE ANTIBIOTIC TETRONASIN (ICI-139603)

被引：11

作者：

DELASZLO, SE ^{[1
]}

FORD, MJ ^{[1
]}

LEY, SV ^{[1
]}

MAW, GN ^{[1
]}

机构：

[1] IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM,LONDON SW7 2AY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)97889-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preparation of a central tetrahydropyran portion (2) of the antibiotic tetronasin (1) was achieved using an all-in-one epoxidation / cyclization modification of the Sharpless reaction. Further manipulation and coupling reactions afforded the C12-C26 fragment of tetronasin which was identical to that obtained by natural product degradation studies. © 1990.

引用

页码：5525 / 5528

页数：4