RENAL UPTAKE OF DIMERCAPTOSUCCINIC ACID AND GLOMERULAR-FILTRATION RATE IN CHRONIC NEPHROPATHY AT ANGIOTENSIN CONVERTING ENZYME-INHIBITION

被引：3

作者：

KAMPER, AL ^{[1
]}

THOMSEN, HS ^{[1
]}

NIELSEN, SL ^{[1
]}

STRANDGAARD, S ^{[1
]}

机构：

[1] UNIV COPENHAGEN,HERLEV HOSP,DEPT NUCL MED,DK-2730 HERLEV,DENMARK

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1990年 / 16卷 / 02期

关键词：

Angiotensin converting enzyme inhibition; Chronic nephropathy; Dimercaptosuccinic acid renal uptake;

D O I：

10.1007/BF01465915

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Glomerular filtration rate (GFR) and renal uptake of dimercaptosuccinic acid (DMSA) were measured in 31 patients with progressive chronic nephropathy before and immediately after the start of treatment with angiotensin converting enzyme (ACE) inhibitor in order to control adverse effects on kidney function. Scintigrams of the kidneys showed an unaltered distribution of DMSA during treatment. GFR estimated by51Cr-EDTA plasma clearance fell by 14% (P < 0.01), but renal uptake of99mTc-DMSA increased by 10% (P < 0.01). It is concluded that DMSA in chronic renal failure is mainly taken up by the tubular cells from the peritubular capillaries since the uptake was unaffected by the acute decrease in GFR. © 1990 Springer-Verlag.

引用

页码：85 / 88

页数：4