SYNTHESIS OF ALPHA-PHENYL PROLINE DERIVATIVES VIA 1,3-DIPOLAR CYCLOADDITION OF CHIRAL STABILIZED AZOMETHINE YLIDS

被引：38

作者：

ANSLOW, AS ^{[1
]}

HARWOOD, LM ^{[1
]}

LILLEY, IA ^{[1
]}

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 10期

关键词：

D O I：

10.1016/0957-4166(95)00321-F

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation of (3S, 5R)-3,5-diphenylmorpholinone 1 and subsequent diastereoselective 1,3-dipolar cycloaddition of its formaldehyde derived azomethine ylid is described. Removal of the chiral template furnishes a-phenyl proline derivatives.

引用

页码：2465 / 2468

页数：4

共 10 条

[1] DEVELOPMENT OF CHIRAL STABILIZED AZOMETHINE YLIDS - COMPLETING THE MEMORY RELAY
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[2] DEVELOPMENT OF CHIRAL STABILIZED AZOMETHINE YLIDES - A CHIRAL MEMORY RELAY SYSTEM
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[3] DEVELOPMENT OF A CHIRAL STABILIZED AZOMETHINE YLID - A CHIRAL RELAY SYSTEM
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[4] SYNTHESIS OF 2,3-DIHYDRO-6H-1,4-OXAZIN-2-ONES CHIRAL AT C(3) AND ASYMMETRIC INDUCTION IN HYDROGENATION OF AZOMETHINE BOND
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[5] SYNTHESIS OF HOMOCHIRAL ALPHA-AMINO-ACIDS BY REDUCTIVE AMINATION OF ALPHA-KETOACIDS VIA 3-SUBSTITUTED-5-PHENYL-3,4-DEHYDROMORPHOLIN-2-ONES - SYNTHESIS OF (S)-2-AMINOBUTANOIC AND (R)-2-AMINOBUTANOIC ACID
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[J]. TETRAHEDRON-ASYMMETRY, 1994, 5 (09) : 1669 - 1672
[6] HARWOOD LM, 1993, SYNLETT, P777
[7] ASYMMETRIC CYCLOADDITIONS OF ALDEHYDES TO STABILIZED AZOMETHINE YLIDS - ENANTIOCONTROLLED CONSTRUCTION OF BETA-HYDROXY-ALPHA-AMINO ACID-DERIVATIVES
HARWOOD, LM
MACRO, J
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[J]. TETRAHEDRON-ASYMMETRY, 1992, 3 (09) : 1127 - 1130
[8] ENANTIOCONTROLLED CONSTRUCTION OF BICYCLIC PROLINE DERIVATIVES VIA ONE-POT GENERATION AND INTRAMOLECULAR TRAPPING OF CHIRAL STABILIZED AZOMETHINE YLIDS
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[9] HARWOOD LM, 1995, TETRAHEDRON ASYMMETR, V6
[10] HARWOOD LM, 1993, TETRAHEDRON LETT, P6603

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