SYNTHESIS OF HOMOCHIRAL ALPHA-AMINO-ACIDS BY REDUCTIVE AMINATION OF ALPHA-KETOACIDS VIA 3-SUBSTITUTED-5-PHENYL-3,4-DEHYDROMORPHOLIN-2-ONES - SYNTHESIS OF (S)-2-AMINOBUTANOIC AND (R)-2-AMINOBUTANOIC ACID

被引：34

作者：

COX, GG ^{[1
]}

HARWOOD, LM ^{[1
]}

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 09期

关键词：

D O I：

10.1016/0957-4166(94)80077-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-Oxobutanoic acid has been converted to (R)-or (S)-2-aminobutanoic acid via highly diastereocontrolled hydrogenation of the corresponding homochiral 3-ethyl-5-phenyl-3,4-dehydromorpholin-2-one derivatives.

引用

页码：1669 / 1672

页数：4

共 11 条

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[7] ENANTIOCONTROLLED CONSTRUCTION OF BICYCLIC PROLINE DERIVATIVES VIA ONE-POT GENERATION AND INTRAMOLECULAR TRAPPING OF CHIRAL STABILIZED AZOMETHINE YLIDS
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[8] HARWOOD LM, 1993, TETRAHEDRON LETT, P6603
[9] A NOVEL ASYMMETRIC-SYNTHESIS OF S-(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID
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