ROLE OF OXIDATIVELY MODIFIED LDL IN ATHEROSCLEROSIS

被引：572

作者：

STEINBRECHER, UP

ZHANG, HF

LOUGHEED, M

机构：

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 02期

基金：

英国医学研究理事会;

关键词：

Aterosclerosis; Free radicals; Lipid peroxidation; Macrophages; Oxidized LDL; Scavenger receptor;

D O I：

10.1016/0891-5849(90)90119-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative modification of LDL is accompanied by a number of compositional and structural changes, including increased electrophoretic mobility, increased density, fragmentation of apolipoprotein B, hydrolysis of phosphatidylcholine, derivatization of lysine amino groups, and generation of lfuorescent adducts due to covalent binding of lipid oxidation products to apo B. In addition, oxidation of LDL has been shown to result in numerous changes in its biologic properties that could have pathogenetic imortance, including accelerated uptake in macrophages, cytotoxicity, and chemotactic activity for monocytes. The present article summarrizes very recent developments related to the mechanism of oxidation of LDL by cells, receptor-mediated uptake of oxidized LDL in macrophages, the mechanism of phosphatidylcholine hydrolysis during LDL oxidation, and other biologic actions of oxidized LDL including cytotoxicity, altered eicosanoid metabolism, and effects on the secretion of growth factors and chemotactic factors. In addition, this review will exzmine the evidence for the presence of oxidized LDL in vivo and the evidence that oxidized LDL plays a pathogenetic role in atherosclerosis. © 1990.

引用

页码：155 / 168

页数：14

共 117 条

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