CHEMOSELECTIVE DEPROTECTION OF BENZYL-ESTERS IN THE PRESENCE OF BENZYL ETHERS, BENZYLOXYMETHYL ETHERS AND N-BENZYL GROUPS BY CATALYTIC TRANSFER HYDROGENATION

被引：53

作者：

BAJWA, JS

机构：

[1] Sandoz Research Institute, Sandoz Inc., New Jersey U.S.A., East Hanover

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 17期

关键词：

CHEMOSELECTIVE; DEPROTECTION; BENZYL GROUPS; CATALYTIC TRANSFER HYDROGENATION;

D O I：

10.1016/S0040-4039(00)74195-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

-COOBn, -PO(OH)OBn, -O-CBz and -N-CBz groups are efficiently and chemoselectively deprotected in the presence of Bn and BOM ethers and N-Bn groups by hydrogenolysis under catalytic transfer hydrogenation using 10 % palladium on carbon as the catalyst and cyclohexadiene as the hydrogen donor.

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页码：2299 / 2302

页数：4

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