ADIPOSTATIN-A AND ADIPOSTATIN-B, NEW INHIBITORS OF GLYCEROL-3-PHOSPHATE DEHYDROGENASE

As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1-mu-M and 4.5-mu-M, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the mu-M level.