RELATIONSHIP OF CIGARETTE-SMOKING TO THE SEVERITY OF CORONARY AND THORACIC AORTIC ATHEROSCLEROSIS

被引:31
作者
INOUE, T [1 ]
OKU, K [1 ]
KIMOTO, K [1 ]
TAKAO, M [1 ]
NOMOTO, J [1 ]
HANDA, K [1 ]
KONO, S [1 ]
ARAKAWA, K [1 ]
机构
[1] NATL DEF MED COLL, DEPT PUBL HLTH, TOKOROZAWA, SAITAMA 359, JAPAN
关键词
CIGARETTE SMOKING; ATHEROSCLEROSIS; AORTA; TRANSESOPHAGEAL ECHOCARDIOGRAPHY;
D O I
10.1159/000176904
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We studied the relationship of cigarette smoking to the severity of coronary and thoracic aortic atherosclerosis in 116 men who received coronary angiography and transesophageal echocardiography. Severity of coronary atherosclerosis was assessed in terms of Gensini's score (GS), and that of thoracic aortic atherosclerosis was assessed by the average sclerotic length (ASL) and average sclerotic area (ASA). The plasma fibrinogen levels were significantly positively correlated with smoking, and fasting blood sugar levels tended to be positively associated with smoking. GS was inversely associated with serum levels of high density lipoprotein (HDL) cholesterol. ASL and ASA were positively associated with age, fasting blood sugar levels and plasma fibrinogen levels, and these associations were statistically significant. Analysis of covariance was used to examine the net association between cigarette smoking and GS, ASL or ASA controlling for age, total cholesterol, HDL cholesterol, fasting blood sugar and plasma fibrinogen. We found that GS, ASL and ASA were all significantly increased with increasing number of cigarette years. Additional adjustment for other risk factors (triglyceride, uric acid, body mass index, alcohol use and hypertension) also showed a strong independent: contribution of smoking to GS, ASL and ASA. We concluded that the cumulative exposure to cigarette smoking was an independent indicator of the severity of coronary atherosclerosis as well as thoracic aortic atherosclerosis.
引用
收藏
页码:374 / 379
页数:6
相关论文
共 32 条
  • [11] SMOKING AS A RISK FACTOR FOR RECURRENCE OF SUDDEN CARDIAC-ARREST
    HALLSTROM, AP
    COBB, LA
    RAY, R
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (05) : 271 - 275
  • [12] HARRELL F, 1982, SAS USERS GUIDE
  • [13] CIGARETTE-SMOKING AND ARTERIOGRAPHICALLY DEMONSTRABLE CORONARY-ARTERY DISEASE
    HERBERT, WH
    [J]. CHEST, 1975, 67 (01) : 49 - 52
  • [14] THE ASCENDING AORTA - HOW MUCH DOES TRANSESOPHAGEAL ECHOCARDIOGRAPHY SEE
    KONSTADT, SN
    REICH, DL
    QUINTANA, C
    LEVY, M
    [J]. ANESTHESIA AND ANALGESIA, 1994, 78 (02) : 240 - 244
  • [15] Lanza G M, 1991, J Am Soc Echocardiogr, V4, P19
  • [16] FIBRINOGEN - A POSSIBLE LINK BETWEEN SOCIAL-CLASS AND CORONARY HEART-DISEASE
    MARKOWE, HLJ
    MARMOT, MG
    SHIPLEY, MJ
    BULPITT, CJ
    MEADE, TW
    STIRLING, Y
    VICKERS, MV
    SEMMENCE, A
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1985, 291 (6505): : 1312 - 1314
  • [17] ADVANCES IN TRANSESOPHAGEAL ECHOCARDIOGRAPHY FOR THE EVALUATION OF ATHEROSCLEROTIC LESIONS IN THORACIC AORTA - THE EFFECTS OF HYPERTENSION, HYPERCHOLESTEROLEMIA, AND AGING ON ATHEROSCLEROTIC LESIONS
    MATSUZAKI, M
    ONO, S
    TOMOCHIKA, Y
    MICHISHIGE, H
    TANAKA, N
    OKUDA, F
    KUSUKAWA, R
    [J]. JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1992, 56 (06): : 592 - 602
  • [18] MEITES S, 1973, CLIN CHEM, V19, P675
  • [19] MIELING GE, 1979, CLIN CHEM, V25, P1581
  • [20] NAEYE RL, 1977, AM J CLIN PATHOL, V68, P493