MENGOVIRUS-INDUCED INHIBITION OF CELL PROTEIN-SYNTHESIS AND SUBSEQUENT RECOVERY OF CELLULAR-ACTIVITY IN INTERFERON-PRETREATED CELLS

被引：14

作者：

FALCOFF, R

SANCEAU, J

机构：

[1] Institut National de la Santé et de la Recherche Médicale, F.R.A. No. 22, Institut Curie, 75231 Paris Cédex 05, 26, rue d'Ulm

来源：

VIROLOGY | 1979年 / 98卷 / 02期

关键词：

D O I：

10.1016/0042-6822(79)90565-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pretreatment of L cells with interferon, 10 to 5000 units/ml, did not impair the shutoff of host protein synthesis induced by mengovirus infection. Under conditions which reduced viral protein synthesis to undetectable levels, [35S]methionine incorporation into cell proteins diminished as an exponential function of the multiplicity of infection. However, this phenomenon was transient, since 6 to 8 hr after infection [35S]methionine incorporation began to rise again. At 24 hr, the pattern of newly synthesized cell proteins was similar to that of uninfected cells. © 1979.

引用

页码：433 / 438

页数：6

共 17 条

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