EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN LARYNGEAL DYSPLASIA AND CARCINOMA

被引：40

作者：

MIYAGUCHI, M

OLOFSSON, J

HELLQUIST, HB

机构：

[1] UNIV HOSP BERGEN,DEPT OTOLARYNGOL HEAD & NECK SURG,BERGEN,NORWAY

[2] LINKOPING UNIV HOSP,DEPT PATHOL,S-58185 LINKOPING,SWEDEN

来源：

ACTA OTO-LARYNGOLOGICA | 1990年 / 110卷 / 3-4期

关键词：

EGFR; Immunohistochemistry; Larynx; Squamous cell lesions;

D O I：

10.3109/00016489009122553

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The immunoreactivity of epidermal growth factor receptor (EGFR) was studied in laryngeal biopsy specimens from 24 patients. The study comprised 5 cases of normal laryngeal mucosa, 5 cases of dysplasia, 7 cases of well differentiated squamous cell carcinoma, and 7 cases of poorly to moderately differentiated squamous cell carcinoma. EGFR was in general not expressed in normal and dysplastic epithelia, whilst all carcinomas showed a rather strong positive immunoreactivity. There was no significant difference in staining patterns between the well and poorly to moderately differentiated carcinomas. The results suggest that EGFR constitutes a component of neoplastic, but probably not preneoplastic, laryngeal disease. The study failed to reveal any difference in staining pattern between different types of laryngeal squamous cell carcinoma. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：309 / 313

页数：5

共 25 条

[21]

RO J, 1988, CANCER RES, V48, P161

[22]

SANTON JB, 1986, CANCER RES, V46, P4701

[23]

Sato J D, 1983, Mol Biol Med, V1, P511

[24] HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR CDNA SEQUENCE AND ABERRANT EXPRESSION OF THE AMPLIFIED GENE IN A431 EPIDERMOID CARCINOMA-CELLS [J].

ULLRICH, A ;

COUSSENS, L ;

HAYFLICK, JS ;

DULL, TJ ;

GRAY, A ;

TAM, AW ;

LEE, J ;

YARDEN, Y ;

LIBERMANN, TA ;

SCHLESSINGER, J ;

DOWNWARD, J ;

MAYES, ELV ;

WHITTLE, N ;

WATERFIELD, MD ;

SEEBURG, PH .

NATURE, 1984, 309 (5967) :418-425

[25]

YASUI W, 1988, CANCER RES, V48, P137

← 1 2 3 →