EFFECTS OF AN RB MUTATION IN THE MOUSE

被引：1536

作者：

JACKS, T

FAZELI, A

SCHMITT, EM

BRONSON, RT

GOODELL, MA

WEINBERG, RA

机构：

[1] MIT,WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02139

[2] TUFTS UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02111

[3] TUFTS UNIV,SCH VET MED,BOSTON,MA 02111

来源：

NATURE | 1992年 / 359卷 / 6393期

关键词：

D O I：

10.1038/359295a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

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页码：295 / 300

页数：6

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