ANTIBODY HMB-45 IDENTIFIES THE CELLS OF BLUE NEVI - AN IMMUNOHISTOCHEMICAL STUDY ON PARAFFIN SECTIONS

被引：59

作者：

SUN, J ^{[1
]}

MORTON, TH ^{[1
]}

GOWN, AM ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT PATHOL,SEATTLE,WA 98195

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 1990年 / 14卷 / 08期

关键词：

antimelanoma antibody (HMB-45); blue nevus; melanocyte; schwann cell;

D O I：

10.1097/00000478-199008000-00006

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Sixteen cases of blue nevi were investigated using the anti-melanoma specific antibody HMB-45. This antibody has been found to react with junctional but not with intradermal nevus cells, and with fetal and neonatal, but not with adult, melanocytes. Our study shows that HMB-45 also reacts with cells of the blue nevus, a unique type of intradermal nevus. The origin of blue nevus cells is controversial, and the results of this study support the hypothesis that blue nevus cells are not of purely melanocytic or Schwannian origin, but are derived from a precursor cell that has some common features of both melanocyte and Schwann cell.

引用

页码：748 / 751

页数：4

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