SUBSTANCE-P RELEASE FROM SPINAL-CORD SLICES BY CAPSAICIN

被引：375

作者：

GAMSE, R

MOLNAR, A

LEMBECK, F

机构：

[1] Institute of Exper. and Clin. Pharmacology, University of Graz

来源：

LIFE SCIENCES | 1979年 / 25卷 / 07期

关键词：

D O I：

10.1016/0024-3205(79)90558-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The release of substance P (SP) from slices of hypothalamus, substantia nigra and spinal cord of the rat was studied. In contrast to 47 mM potassium, capsaicin induced SP release from spinal cord slices only. The SP release was not reduced by 10-6 M tetrodotoxin but was abolished by a Ca2+ free medium containing 3 mM ethylene-glycol-bis- (β-aminoethyl-ether) N,N-tetraacetic acid (EGTA). Capsaicin induced SP release was dose-dependent and exhibited tachyphylaxis. The ability of capsaicin to release SP supports the hypothesis that SP is involved in pain transmission and in neurogenic plasma extravasation. © 1979.

引用

页码：629 / 636

页数：8

共 23 条

[11] STIMULATION AND DESENSITIZATION OF HYPOTHALAMIC HEAT-SENSITIVE STRUCTURES BY CAPSAICIN IN RATS
JANCSOGABOR, A
SZOLCSANYI, J
JANCSO, N
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1970, 208 (02): : 449 - +
[12] CAPSAICIN-INDUCED DEPLETION OF SUBSTANCE-P FROM PRIMARY SENSORY NEURONS
JESSELL, TM
IVERSEN, LL
CUELLO, AC
[J]. BRAIN RESEARCH, 1978, 152 (01) : 183 - 188
[13] SUBSTANCE-P RELEASE FROM RAT SUBSTANTIA NIGRA
JESSELL, TM
[J]. BRAIN RESEARCH, 1978, 151 (03) : 469 - 478
[14] KATZ B, 1976, P ROY SOC B, V167, P8
[15] LEMBECK F, 1953, N-S ARCH EX PATH PH, V219, P197
[16] LEMBECK F, 1977, SUBSTANCE P, P169
[17] EVIDENCE FOR SUBSTANCE-P IN STRIATO-NIGRAL TRACT
MROZ, EA
BROWNSTEIN, MJ
LEEMAN, SE
[J]. BRAIN RESEARCH, 1977, 125 (02) : 305 - 311
[18] EFFECTS OF CAPSAICIN ON HYPOTHALAMIC THERMO-SENSITIVE NEURONS IN RAT
NAKAYAMA, T
SUZUKI, M
ISHIKAWA, Y
NISHIO, A
[J]. NEUROSCIENCE LETTERS, 1978, 7 (2-3) : 151 - 155
[19] NILSSON G, 1977, SUBSTANCE P, P49
[20] RELEASE OF SUBSTANCE P-LIKE IMMUNOREACTIVITY FROM DENTAL-PULP
OLGART, L
GAZELIUS, B
BRODIN, E
NILSSON, G
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1977, 101 (04): : 510 - 512

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