IONTOPHORETIC TRANSPORT THROUGH POROUS MEMBRANES USING SCANNING ELECTROCHEMICAL MICROSCOPY - APPLICATION TO INVITRO STUDIES OF ION FLUXES THROUGH SKIN

被引：139

作者：

SCOTT, ER

WHITE, HS

PHIPPS, JB

机构：

[1] UNIV MINNESOTA, DEPT CHEM ENGN & MAT SCI, MINNEAPOLIS, MN 55455 USA

[2] ALZA CORP, SPRING LAKE PK, MN 55432 USA

来源：

ANALYTICAL CHEMISTRY | 1993年 / 65卷 / 11期

关键词：

D O I：

10.1021/ac00059a010

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Scanning electrochemical microscopy (SECM) is used to map localized iontophoretic fluxes of electroactive species through porous membranes. A method is described that allows both the rate of transport of species from a microscopic pore and the pore's diameter to be measured. SECM images and analyses of synthetic porous membranes (track-etched polycarbonate and mica membranes) and hairless mouse skin are reported. Preliminary analysis of SECM images of the mouse skin indicates that a significant percentage of the iontophoretic flux occurs through pores associated with hair follicles.

引用

页码：1537 / 1545

页数：9

共 22 条

[1]

Adams R. N., 1969, ELECTROCHEMISTRY SOL

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