1,4-DIAZABICYCLO[2.2.2]OCTANE (DABCO)-CATALYZED HYDROLYSIS AND ALCOHOLYSIS REACTIONS OF 2-AMINO-9-BENZYL-6-CHLORO-9H-PURINE

被引：43

作者：

LINN, JA

MCLEAN, EW

KELLEY, JL

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 08期

关键词：

D O I：

10.1039/c39940000913

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Amino-9-benzyl-6-chloro-9H-purine 1 is hydrolysed in refluxing water in the presence of 1,4-diazabicycle [2.2.2] octane (DABCO) to give 2-amino-9-benzyl-1,6-dihydro-6-oxo-9H-purine 3; however, 1 reacts with hydroxide ion at ambient temp., or an alcohol and potassium carbonate at elevated temperatures, in the presence of DABCO to give 3 or 6-alkoxy-2-amino-9-benzyl-9H-purines 4-8, respectively.

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页码：913 / 914

页数：2

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