TARGETS FOR ANTIINFLAMMATORY DRUGS

被引：43

作者：

CRONSTEIN, BN

WEISSMANN, G

机构：

[1] Department of Medicine, Division of Rheumatology, New York University Medical Center, New York, NY 10016

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 1995年 / 35卷

关键词：

CORTICOSTEROIDS; METHOTREXATE; NONSTEROIDAL ANTIINFLAMMATORY AGENTS; ADHESION;

D O I：

10.1146/annurev.pa.35.040195.002313

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aspirin-like nonsteroidal antiinflammatory agents, corticosteroids, and methotrexate are the mainstays of therapy in rheumatoid arthritis and other inflammatory diseases. It is now clear that these agents share at least one characteristic: All of these agents diminish the adhesive interactions required for the accumulation of white blood cells at an inflamed site. We discuss the biochemical and functional mechanisms by which these drugs alter the inflammatory response, and the potential for development of new antiinflammatory agents based upon these pharmacological actions.

引用

页码：449 / 462

页数：14

共 72 条

[11] ACTION OF STEROIDS AND STREPTOLYSIN S ON PERMEABILITY OF PHOSPHOLIPID STRUCTURES TO CATIONS [J].