TANDEM MASS-SPECTROMETRY - QUADRUPOLE AND HYBRID INSTRUMENTS

被引:55
作者
YOST, RA
BOYD, RK
机构
[1] UNIV FLORIDA, DEPT CHEM, GAINESVILLE, FL 32611 USA
[2] NATL RES COUNCIL CANADA, ATLANTIC REG LAB, INST MARINE BIOSCI, HALIFAX B3H 3Z1, NS, CANADA
关键词
D O I
10.1016/0076-6879(90)93415-H
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This chapter discusses quadrupole and hybrid instruments of tandem mass spectrometry. The general concept of tandem mass spectrometry (MS/MS) as a tool that delineates connectivity relationships between precursor and product ions are reviewed briefly in the chapter. The present chapter is mainly concerned with instruments, designed specifically for experiments of this type, which use quadrupole mass filters as analyzers for the product ion(s) finally detected in the experiment. The precursor ion analyzer is most frequently another quadrupole (the triple quadrupole instruments), but an increasing number of tandem instruments incorporate a sector analyzer as the first stage; such “hybrid” instruments combine the high-mass/high-resolution advantages of the modern sector instrument with the flexibility of the quadrupole. The present chapter contains four main sections. The first two of these cover material (general concepts of tandem mass spectrometry and operational properties of rf-only quadrupoles) pertinent to both kinds of XqQ instruments. Each of the two remaining sections is devoted to one of these two types, their special advantages and problems, and is illustrated, where appropriate, by examples from the recent literature. The chapter concludes with a summary and discussion of future directions. © 1990, Elsevier Inc. All rights reserved.
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页码:154 / 200
页数:47
相关论文
共 109 条
  • [41] A NEW HYBRID SECTOR QUADRUPOLE MASS-SPECTROMETER FOR MASS-SPECTROMETRY MASS-SPECTROMETRY
    GLISH, GL
    MCLUCKEY, SA
    RIDLEY, TY
    COOKS, RG
    [J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1982, 41 (03): : 157 - 177
  • [42] GLISH GL, 1980, THESIS PURDUE U W LA
  • [43] TANDEM MASS-SPECTROMETRY - MULTISECTOR MAGNETIC INSTRUMENTS
    GROSS, ML
    [J]. METHODS IN ENZYMOLOGY, 1990, 193 : 131 - 153
  • [44] OPERATION OF A HYBRID TANDEM MASS-SPECTROMETER OF BEQQ CONFIGURATION IN SCAN MODES USING UNCOUPLED ANALYZERS
    GUEVREMONT, R
    BOYD, RK
    [J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1988, 84 (1-2): : 47 - 67
  • [45] GUEVREMONT R, 1988, RAPID COMMUN MASS SP, V2, P47
  • [46] NEW ION-OPTICAL DEVICES UTILIZING OSCILLATORY ELECTRIC-FIELDS .4. COMPUTER-SIMULATIONS OF THE TRANSPORT OF AN ION-BEAM THROUGH AN IDEAL QUADRUPOLE, HEXAPOLE, AND OCTOPOLE OPERATING IN THE RF-ONLY MODE
    HAGG, C
    SZABO, I
    [J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1986, 73 (03): : 295 - 312
  • [47] HAIL ME, 1990, CURRENT RES PROTEIN
  • [48] QUANTITATIVE-ANALYSIS OF PLATELET ACTIVATING FACTOR USING FAST ATOM BOMBARDMENT TANDEM MASS-SPECTROMETRY
    HAROLDSEN, PE
    GASKELL, SJ
    [J]. BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1989, 18 (06): : 439 - 444
  • [49] A NOVEL SPECTROMETER, INCORPORATING AN ELECTRIC SECTOR AND QUADRUPOLE MASS FILTER, FOR STUDYING DISSOCIATIONS OF IONS
    HARRIS, FM
    KEENAN, GA
    BOLTON, PD
    DAVIES, SB
    SINGH, S
    BEYNON, JH
    [J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1984, 58 (JUN): : 273 - 292
  • [50] A HYBRID BEQQ MASS-SPECTROMETER FOR STUDIES IN GASEOUS ION CHEMISTRY
    HARRISON, AG
    MERCER, RS
    REINER, EJ
    YOUNG, AB
    BOYD, RK
    MARCH, RE
    PORTER, CJ
    [J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1986, 74 (01): : 13 - 31