STIMULATION OF CD2-NEGATIVE T-CELLS BY STAPHYLOCOCCAL-ENTEROTOXIN SUPERANTIGENS

被引：2

作者：

DUAN, XC ^{[1
]}

KABELITZ, D ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST IMMUNOL,NEUENHEIMER FELD 305,W-6900 HEIDELBERG,GERMANY

来源：

IMMUNOLOGY LETTERS | 1991年 / 29卷 / 03期

关键词：

CD2-NEGATIVE T-CELL; STAPHYLOCOCCAL ENTEROTOXIN; SUPERANTIGEN; T-CELL ACTIVATION;

D O I：

10.1016/0165-2478(91)90173-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A minor fraction of CD3+ T cells lacks expression of the CD2 antigen, which is the target for an "alternative" T cell activation pathway. CD2- CD3+ T cells can be stimulated by anti-CD3 or anti-T cell receptor (TCR) antibodies, indicating that the CD3/TCR signal transduction pathway functions in the absence of cell surface CD2. In the present study we have analyzed whether CD2- CD3+ T cells also respond to antigen stimulation. We show here that cloned CD2-negative T cells expressing the alpha/beta-TCR are activated by one or several staphylococcal enterotoxin "superantigens". Activation of CD2- CD3+ T cell clones by staphylococcal enterotoxins resulted in IL-2 production and/or proliferative activity, and was dependent on the presence of HLA class II-bearing feeder cells. These data demonstrate that T cells can recognize (and respond to) antigen in the absence of a functional CD2 molecule.

引用

页码：219 / 222

页数：4

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