LONG-TERM PRODUCTION AND DELIVERY OF HUMAN GROWTH-HORMONE IN-VIVO

被引：46

作者：

HEARTLEIN, MW ^{[1
]}

ROMAN, VA ^{[1
]}

JIANG, JL ^{[1
]}

SELLERS, JW ^{[1
]}

ZULIANI, AM ^{[1
]}

TRECO, DA ^{[1
]}

SELDEN, RF ^{[1
]}

机构：

[1] TKT INC,CAMBRIDGE,MA 02139

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 23期

关键词：

NONVIRAL GENE THERAPY; SKIN FIBROBLASTS; SOMATOTROPIN;

D O I：

10.1073/pnas.91.23.10967

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The application of somatic cell gene therapy to large patient populations will require the development of safe and practical approaches to the generation and characterization of genetically manipulated cells. Transkaryotic implantation is a gene therapy system based on the production of clonal strains of engineered primary and secondary cells, using nonviral methods. We demonstrate here that, on implantation, these clonal cell strains stably and reproducibly deliver pharmacologic quantities of protein for the lifetime of the experimental animals.

引用

页码：10967 / 10971

页数：5

共 35 条

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