2 NEW PHOSPHOLIPASE-D INHIBITORS, SCH-49211 AND SCH-49212, PRODUCED BY THE FUNGUS NATTRASSIA-MANGIFERAE

被引：17

作者：

CHU, M

TRUUMEES, I

PATEL, MG

GULLO, VP

PAI, JK

DAS, PR

PUAR, MS

机构：

[1] Schering-Plouhg Research Insititute, Kenilworth, NJ 07033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80529-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sch 49211 (2) and Sch 49212 (3) have been isolated from the fermentation of the fungus Nattrassia mangiferae. The strucutres of 2 and 3 were determined by analysis of NMR spectroscopic data. Both 2 and 3 exhibit inhibitory activity (IC50 = 11 and 12 mu M, respectively) in the phospholipase D (PLD) assay.

引用

页码：1539 / 1542

页数：4

共 3 条

[1]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[2] STRUCTURE OF SCH-49209 - A NOVEL ANTITUMOR AGENT FROM THE FUNGUS NATTRASSIA-MANGIFERAE [J].